The IONS laboratory is one of a few in the world devoted to studying the relationship between consciousness and the physical world. The lab houses a broad array of instrumentation, ranging from psychophysiological monitors of autonomic and central nervous system activity (e.g., electrocardiogram, heart rate, skin conductance, electrogastrogram, respiration, blood flow, 32 channel EEG), to physical detectors of mind-matter interaction (e.g., random event generators, optical interferometers, magnetometers, speed of light measurements). A fully networked infrastructure allows high speed within-lab and Internet access, and a solid steel, double-walled, electromagnetically shielded room provides ample space for studies requiring energetic or sensory isolation.